![]() The concentration of active substance in plasma is a linear function of the applied dose. Time to reach C max in plasma after oral administration is 2-4 hours depending on the used dosage form, after rectal - 1 h, I.M. About 50% of the active substance is metabolized in the "first passage" through the liver. Eating slows down the rate of absorption, extent of absorption is not changed. When used topically in ophthalmology reduces swelling and pain in inflammatory processes non-infectious etiology.Īfter intake is absorbed from the gastrointestinal tract. With prolonged use has a desensitizing effect. In rheumatic diseases, Dealgic reduces joint pain at rest and in motion, as well as morning stiffness and swelling of the joints, helps to increase range of motion reduces post-traumatic and postoperative pain, and inflammatory edema. Inhibits synthesis of proteoglycan in cartilage. Analgesic effect is due to two mechanisms: peripheral and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. NSAIDs, a derivative of phenylacetic acid, Dealgic has a pronounced anti-inflammatory, analgesic and mild antipyretic effect. ![]()
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